'Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003-2004. By absorbing UV rays, it also helps preserve the integrity of other cosmetic ingredients . The U.S. Food and Drug Administration today issued a proposed rule that would update regulatory requirements for most sunscreen products in the United States. Exposing unprotected skin to UV . Benzophenone ingredients absorb and dissipate UV radiation, which serves to protect cosmetics and personal care products. Benzophenone is activated by . Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical . The Center. We examined the effects of oxybenzone on the larval form (planula) of . As part of sunscreen products, which are OTC drugs in the United States, Benzophenone-3 (Oxybenzone) and Benzophenone-4 (Sulisobenzone) protect the skin from the harmful effects of the sun. They are both very stable and protect and augment other UV absorbers. It is used mostly in the formulation of nail polishes and enamels, but can also be used in bath products, makeup products, hair products, sunscreens and skin care . The objective of this study was to develop a rapid, selective and accurate method by reversed-phase HPLC for quantitative simultaneous determination of benzophenone-3 (B-3) and octyl methoxycinnamate (OM) contained in sunscreen emulsions. The U.S. Food and Drug Administration (FDA) has approved benzophenone-3 (BP3), also known as oxybenzone, as an active ingredient in sunscreen. 1 Oxybenzone (Benzophenone-3) Oxybenzone (also called "benzophenone-3" or "BP-3") is an organic compound used as an ingredient in sunscreens because it absorbs UVB and UVA rays. 'Safety of oxybenzone: putting numbers into perspective'. The common sunscreen ingredient benzophenone-3, also known as oxybenzone or BP-3, can play a role in the development of mammary gland tumors, according to new research in mice. Epidemiologic and public health surveys often rely on self-reported sunscreen use to estimate sun exposure and avoidance, but questions remain about the validity of self-reports. Downs CA, Kramarsky-Winter E, Segal R, et al. Products Ingredients Decode INCI Login Register Substituted benzophenones such as oxybenzone and dioxybenzone are used in sunscreen.3.1Computed Properties. 101, pages 285-304. Oxybenzone, also called BP-3 or Benzophenone-3, is found commonly in sunscreens and make-up with SPF protection. BP-3 is also added to packaging and some consumer products, such as cosmetics and paints, to protect the products from sun damage. Jun 6th, 2017. According to the Cosmetics Regulation (No. Benzophenone is used as an ultraviolet (UV)-curing agent in sunglasses, and to prevent UV light from damaging scents and colours in . Both cover UVB and short UVA (UVA-2) range but are relatively weak sunscreens, inadequate when used alone. These compounds are powders. BP-3 can be used at levels of up to 5-6% as an active ingredient in sunscreen in Japan and the U.S.A. There is a clear connection between the levels of benzophenone-3 in urine and the use of sunscreen. Oxybenzone is known to cause allergic skin reactions. Intensifying her concern is the FDA's 2020 finding that six sunscreen ingredients avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate were absorbed through the skin . Oxybenzone or benzophenone-3 or BP-3 (trade names Milestab 9, Eusolex 4360, Escalol 567, KAHSCREEN BZ-3) is an organic compound.It is a pale-yellow solid that is readily soluble in most organic solvents. It is an oil soluble powder for broad spectrum protection of approximately 1.5 SPF units/percent. It can be confusing to know what look for in sunscreen products, especially since there is no consistent answer or 'reef-safe' standards. This . Benzophenone-3 (2-hydroxy-4-methoxybenzophenone; BP-3) is widely used as sunscreen for protection of human skin and hair from damage by ultraviolet (UV) radiation. . Unlike many other chemical sunscreens, it. On the basis of safety assessment, and considering the concerns related to potential endocrine disrupting properties of benzophenone-3 (BP-3), the SCCS has concluded that: a. Chemical Name: Benzophenone-3 MF: C14H12O3 Cas No. Property Name Property Value Reference; Covalently-Bonded Unit Count: 1: . The safety of Benzophenone-3 and related ingredients has been assessed by the Cosmetic Ingredient Review (CIR) Expert . We investigated whether urinary BP-3 levels were related to ANA in adolescents and young adults. In a forthcoming manuscript, we describe the induction of ossification of the planulae from exposure to benzophenone-3 (oxybenzone, BP-3), a structurally similar compound to BP-2. BP-3 was detected in 96% of the population of the United States between 2003 and 2012. In addition, a Cosmetic Ingredient Review (CIR) expert scientific panel states that benzophenone and its derivatives (benzophenone-1, -3, -4, -5, -9 and -11) are safe as typically used in cosmetics and . For more information: Sun safety tips: Inadequate when used alone, benzophenone-3 absorbs UVB and short UVA rays but is a relatively weak chemical UV absorber. US Department of Health Human Services (HHS) Toxicology Program (NTP) Benzophenone-3 (oxybenzone) is used in many sunscreens and some other personal care products to protect skin from sun damage. Benzophenone-3 (Oxybenzone) and Benzophenone-4 (Sulisobenzone) are chemical UV absorbers solid (powder) at normal temperature. Benzophenone-3 finds application in . You'll find this ingredient in many sunscreens today, including regular lotion sunscreens and makeup foundations with an SPF. How is benzophenone used? The substance can be found in . It is a white solid that is soluble in organic solvents. BP-3 also is used in plastic products to block and prevent UV rays from altering the plastic . Their mean particle size (Z-Ave) ranged from 280 to 420 nm, polydispersity index . : 131-57-7 Appearance: White Powder Product Information: Cosmetic skin care product Benzophenone-3 is a white or pale yellow powder. In all of the above cases, where Benzophenone-3 is used above 0.5% the warning "Contains Benzophenone-3" must be present on packaging. Benzophenone-3 is taken up by the skin and can be found in both blood and breast milk [11]. 1 Oxybenzone or Benzophenone-3. Benzophenone-3 (BP-3; oxybenzone) is an ingredient in sunscreen lotions and personal-care products that protects against the damaging effects of ultraviolet light. BP-3 has other uses in many consumer products (e.g., as fragrance and flavor enhancer, photoinitiator, ultraviolet curing agent, polymerization inhibitor).ObjectivesOur goal was to assess exposure to BP-3 in a representative sample of the U.S. general . Even though it is a sunscreen and its efficacy is up to 3-4 hours depending upon the exposure. Benzophenone-3 or Oxybenzone or BP-3 (trade names Milestab 9, Eusolex 4360, Escalol 567, KAHSCREEN BZ-3) is an organic compound. Benzophenone-3 (BP-3) is a naturally occurring chemical found in some flowering plants. It actually protects you with uvb ray. SCCP adopted at its 10th plenary meeting on 19 of December 2006 an opinion (SCCP/1069/06) on Benzophenone-3 with the conclusion: In this cross-sectional study of NHANES participants ages 12-39, we found that elevated urinary BP-3 concentrations were related to ANA among those who were . It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays. World Health Organization (WHO) International Agency for Research on Cancer (IARC) "Benzophenone" section in Some Chemicals Present in Industrial and Consumer Products, Food and Drinking-Water (2013), vol. Benzophenone sunscreens Chlorpromazine most often causes photosensitivity reactions (incidence around 3%), which may result from formation of a cytotoxic by-product after exposure to ultraviolet light.Patients should be advised to avoid prolonged exposure to strong indoor light, to wear protective clothing, and to use a combined para-aminobenzoic acid plus benzophenone sunscreen when exposure . The Center for Disease Control fourth national report on human exposure to environmental chemicals demonstrated It is a pale-yellow solid that is readily soluble in most organic . They are absorbed by the skin and reflect some of the sun's UV . Benzophenone-3 (Oxybenzone) CAS Number: 131-57-7. Benzophenone 3 is a sunscreen that prevents sunburn and protects skin from the harmful effects of the sun. Benzophenone-3 (BP-3) is one such chemical with increasing exposure through sunscreen use. Another issue is with benzophenone (BP), which as noted can be released in the environment from sunscreens and is a suspected indirect endocrine disrupter. Oxybenzone is an emerging contaminant of concern in marine environments-produced by swimmers and municipal, residential, and boat/ship wastewater discharges. It is also used as a UV stabilizer in plastic surface coatings and polymers.Benzophenone-3 is a common ingredient in sun-blocking agents. 1. There is a clear connection between the levels of benzophenone-3 in urine and the use of sunscreen [14]. Benzophenone-3 (2-hydroxy-4-methoxybenzophenone) occurs naturally in some flowering plants. Arch Environ Contam Toxicol 2015 Oct 20. doi: 10.1007/s00244-015-0227-7. Oxybenzone (Benzophenone-3) is an emerging human and environmental contaminant used in sunscreens and personal care products to help minimize the damaging effects of ultraviolet radiation. It is important to note that Benzophenone is the chemical being discussed and not Benzophenone-3 (Oxybenzone) or Benzophenone-8 (Dioxybenzone), both of which are FDA-approved topical sunscreen active ingredients. Sunscreens: B-3 presents its maximum UV absorption between 288 and 289 nm and absorbs UVA as well as UVB . SCCP/1201/08 Opinion on benzophenone-3 5 1. A chemical sunscreen agent that absorbs UVB and short UVA rays (280-350nm) with its peak protection at 288 nm. For this reason, it is produced for use as sunscreen in lotions, conditioners, and cosmetics. Designated Chemical.